Synthesis of 1,1-Disubstituted Indenes and Dihydronaphthalenes through C–C/C–C Bond-Forming Pd-Catalyzed Autotandem Reactions

Synthesis of Saturated Five-Membered Nitrogen Heterocycles via Pd-Catalyzed C N Bond-Forming Reactions

Saturated five-membered nitrogen heterocycles, such as pyrrolidines, indolines, and isoxazolidines, appear as subunits in a broad array of biologically active and medicinally significant molecules [1]. As such, the synthesis of these compounds has been of longstanding interest. Many classical approaches to the construction of these heterocycles involve the use of C N bond-forming reactions such...

) Bond Forming Reactions

___________________________________________________________________________________________ Abstract Although iron was known and widely used by people for hundreds of years, Grignard reagents also used for about a century, binding together these two concepts still took a long time and surprisingly it did not become a hot topic in chemistry until this decade. This paper is presenting several dev...

Synthesis of chromans via Pd-catalyzed alkene carboetherification reactions.

A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C-O bond and a C-C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives.

Exploiting the C-H bond in metal-catalyzed C-C bond-forming reactions

This account summarizes our work in the field of direct C-H bond functionalization. We have explored methods in the area of directing group assisted C(sp 2 )-H and C(sp 3 )-H activation and investigated arylation as well as deuteration reactions. In these transformations either ruthenium or palladium catalysts were applied. In case of C(sp 2 )-H activation, we developed a protocol for the synth...

Gold(I)-catalyzed enantioselective synthesis of functionalized indenes.